Nightshade, Deadly (Atropa belladonna LINN.) Click on graphic for larger image

Nightshade, Deadly

POISON!
Steadman Shorter's Medical Dictionary,

Botanical: Atropa belladonna (LINN.)
Family: N.O. Solanaceae

• Description
• History
• Cultivation
• Constituents
• Medicinal Action and Uses
• Preparations and Dosages

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---Description---The root is thick, fleshy and whitish, about 6 inches long, or more, and branching. It is perennial. The purplishcoloured stem is annual and herbaceous. It is stout, 2 to 4 feet high, undivided at the base, but dividing a little above the ground into three - more rarely two or four branches, each of which again branches freely.

The leaves are dull, darkish green in colour and of unequal size, 3 to 10 inches long, the lower leaves solitary, the upper ones in pairs alternately from opposite sides of the stem, one leaf of each pair much larger than the other, oval in shape, acute at the apex, entire and attenuated into short petioles.

First-year plants grow only about 1 1/2 feet in height. Their leaves are often larger than in full-grown plants and grow on the stem immediately above the ground. Older plants attain a height of 3 to 5 feet, occasionally even 6 feet, the leaves growing about 1 to 2 feet from the ground.

The whole plant is glabrous, or nearly so, though soft, downy hairs may occur on the young stems and the leaves when quite young. The veins of the leaves are prominent on the under surface, especially the midrib, which is depressed on the upper surface of the leaf.

The fresh plant, when crushed, exhales a disagreeable odour, almost disappearing on drying, and the leaves have a bitter taste, when both fresh and dry.

The flowers, which appear in June and July, singly, in the axils of the leaves, and continue blooming until early September, are of a dark and dingy purplish colour, tinged with green, large (about an inch long), pendent, bell-shaped, furrowed, the corolla with five large teeth or lobes, slightly reflexed. The five-cleft calyx spreads round the base of the smooth berry, which ripens in September, when it acquires a shining black colour and is in size like a small cherry. It contains several seeds. The berries are full of a dark, inky juice, and are intensely sweet, and their attraction to children on that account, has from their poisonous properties, been attended with fatal results. Lyte urges growers 'to be carefull to see to it and to close it in, that no body enter into the place where it groweth, that wilbe enticed with the beautie of the fruite to eate thereof.' And Gerard, writing twenty years later, after recounting three cases of poisoning from eating the berries, exhorts us to 'banish therefore these pernicious plants out of your gardens and all places neare to your houses where children do resort.' In September, 1916, three children were admitted to a London hospital suffering from Belladonna poisoning, caused, it was ascertained, from having eaten berries from large fruiting plants of Atropa Belladonna growing in a neighbouring public garden, the gardener being unaware of their dangerous nature, and again in 1921 the Norwich Coroner, commenting on the death of achild from the same cause, said that he had had four not dissimilar cases previously.

It is said that when taken by accident, the poisonous effects of Belladonna berries may be prevented by swallowing as soon as possible an emetic, such as a large glass of warm vinegar or mustard and water. In undoubted cases of this poisoning, emetics and the stomach-pump are resorted to at once, followed by a dose of magnesia, stimulants and strong coffee, the patient being kept very warm and artificial respiration being applied if necessary. A peculiar symptom in those poisoned by Belladonna is the complete loss of voice, together with frequent bending forward of the trunk and continual movements of the hands and fingers, the pupils of the eye becoming much dilated.

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---History---The plant in Chaucer's days was known as Dwale, which Dr. J. A. H. Murray considers was probably derived from the Scandinavian dool, meaning delay or sleep. Other authorities have derived the word from the French deuil (grief), a reference to its fatal properties.

Its deadly character is due to the presence of an alkaloid, Atropine, 1/10 grain of which swallowed by a man has occasioned symptoms of poisoning. As every part of the plant is extremely poisonous, neither leaves, berries, nor root should be handled if there are any cuts or abrasions on the hands. The root is the most poisonous, the leaves and flowers less so, and the berries, except to children, least of all. It is said that an adult may eat two or three berries without injury, but dangerous symptoms appear if more are taken, and it is wiser not to attempt the experiment. Though so powerful in its action on the human body, the plant seems to affect some of the lower animals but little. Eight pounds of the herb are said to have been eaten by a horse without causing any injury, and an ass swallowed 1 lb. of the ripe berries without any bad results following. Rabbits, sheep, goats and swine eat the leaves with impunity, and birds often eat the seeds without any apparent effect, but cats and dogs are very susceptible to the poison.

Belladonna is supposed to have been the plant that poisoned the troops of Marcus Antonius during the Parthian wars. Plutarch gives a graphic account of the strange effects that followed its use.

Buchanan relates in his History of Scotland (1582) a tradition that when Duncan I was King of Scotland, the soldiers of Macbeth poisoned a whole army of invading Danes by a liquor mixed with an infusion of Dwale supplied to them during a truce. Suspecting nothing, the invaders drank deeply and were easily overpowered and murdered in their sleep by the Scots.

According to old legends, the plant belongs to the devil who goes about trimming and tending it in his leisure, and can only be diverted from its care on one night in the year, that is on Walpurgis, when he is preparing for the witches' sabbath. The apples of Sodom are held to be related to this plant, and the name Belladonna is said to record an old superstition that at certain times it takes the form of an enchantress of exceeding loveliness, whom it is dangerous to look upon, though a more generally accepted view is that the name was bestowed on it because its juice was used by the Italian ladies to give their eyes greater brilliancy, the smallest quantity having the effect of dilating the pupils of the eye.

Another derivation is founded on the old tradition that the priests used to drink an infusion before they worshipped and invoked the aid of Bellona, the Goddess of War.

The generic name of the plant, Atropa, is derived from the Greek Atropos, one of the Fates who held the shears to cut the thread of human life - a reference to its deadly, poisonous nature.

Thomas Lupton (1585) says: 'Dwale makes one to sleep while he is cut or burnt by cauterizing.' Gerard (1597) calls the plant the Sleeping Nightshade, and says the leaves moistened in wine vinegar and laid on the head induce sleep.

Mandrake, a foreign species of Atropa (A. Mandragora), was used in Pliny's day as an anaesthetic for operations. Its root contains an alkaloid, Mandragorine. The sleeping potion of Juliet was a preparation from this plant - perhaps also the Mandrake wine of the Ancients. It was called Circaeon, being the wine of Circe.

Belladonna is often confused in the public mind with dulcamara (Bittersweet), possibly because it bears the popular name of woody nightshade. The cultivation of Belladonna in England dates at least from the sixteenth century, for Lyte says, in the Niewe Herball, 1578: 'This herbe is found in some places of this Countrie, in woods and hedges and in the gardens of some Herboristes.' Though not, however, much cultivated, it was evidently growing wild in many parts of the country when our great Herbals were written. Gerard mentions it as freely growing at Highgate, also at Wisbech and in Lincolnshire, and it gave a name to a Lancashire valley. Under the name of Solanum lethale, the plant was included in our early Pharmacopoeias, but it was dropped in 1788 and reintroduced in 1809 as Belladonna folia. Gerard was the first English writer to adopt the Italian name, of which he makes two words. The root was not used in medicine here until 1860, when Peter Squire recommended it as the basis of an anodyne liniment.

Before the War, the bulk of the world's supply of Belladonna was derived from plants growing wild on waste, stony places in Southern Europe. The industry was an important one in Croatia and Slavonia in South Hungary, the chief centre for foreign Belladonna, the annual crop in those provinces having been estimated at 60 to 100 tons of dry leaves and 150 to 200 tons of dry root. In 1908 the largest exporter in Slavonia is said to have sent out 29,880 lb. of dry Belladonna root.

The Balkan War of 1912-13 interrupted the continuity of Belladonna exports from South Hungary. Stocks of roots and leaves made shorter supplies last out until 1914, when prices rose, owing to increasing scarcity roots which realized 45s. per cwt. in January, 1914, selling for 65s. in June, 1914. With the outbreak of the Great War and the consequent entire stoppage of supplies, the price immediately rose to 100s. per cwt., and soon after, from 300s. to 480s. per cwt. or more. The dried leaves, from abroad, which in normal times sold at 45s. to 50s. per cwt., rose to 250s. to 350s. or more, per cwt. In August, 1916, the drug Atropine derived from the plant had risen from 10s. 6d. per oz. before the War to L. 7 (pounds sterling) per OZ.

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---Cultivation---Belladonna herb and root are sold by analysis, the value depending upon the percentage of alkaloid contained. A wide variation occurs in the amount of alkaloid present. It is important, therefore, to grow the crop under such conditions of soil and temperature as are likely to develop the highest percentage of the active principle.

In connexion with specimens of the wild plant, it is most difficult to trace the conditions which determine the variations, but it has been ascertained that a light, permeable and chalky soil is the most suitable for this crop. This, joined to a south-west aspect on the slope of a hill, gives specially good results as regards a high percentage of alkaloids. The limits of growth of Belladonna are between 50 degrees and 55 degrees N. Lat. and an altitude of 300 to 600 feet, though it may descend to sealevel where the soil is calcareous, especially where the drainage is good and the necessary amount of shade is found. The question of suitability of soil is especially important. Although the cultivated plant contains less alkaloid than that which grows wild, this in reality is only true of plants transported to a soil unsuited to them. It has been found, on the contrary, that artificial aids, such as the judicious selection of manure, the cleansing and preparation of the soil, destruction of weeds, etc., in accordance with the latest scientific practice, have improved the plants in every respect, not only in bulk, but even in percentage weight of alkaloidal contents.

Authorities differ on the question of manuring. Some English growers manure little if the plants are strong, but if the soil is really poor, or the plants are weak, the crop may be appreciably increased by the use of farmyard manure, or a mixture of nitrate of soda, basic slag and kainit. Excellent results have been obtained in experiments, by treating with basic slag, a soil already slightly manured and naturally suited to the plant, the percentage of total alkaloid in dry leaf and stem from third-year plants amounting to 0.84. In this case, the season was, however, an exceptionally favourable one, and, moreover, the soil being naturally suited to the plant, the percentage of alkaloid obtained without added fertilizer was already high. Speaking from the writer's own experience, Belladonna grows in her garden at Chalfont St. Peter. The soil is gravelly even stony in some parts, with a chalk subsoil - the conditions similar to those that the plant enjoys in its wild state. This neighbourhood, in her opinion, is a suitable one for growing fields of Belladonna as crops for medicinal purposes.

Notes and statistics taken from season to season, extending over nine years, have shown that atmospheric conditions have a marked influence on the alkaloidal contents of Belladonna, the highest percentage of alkaloid being yielded in plants grown in sunny and dry seasons. The highest percentage of alkaloid, viz. 0.68 per cent, was obtained from the Belladonna crop of 1912, a year in which the months May and June were unusually dry and sunny; the lowest, just half, 0.34 was obtained on the same ground in 1907, when the period May and June was particularly lacking in sunshine. In 1905, August and September proving a very wet season, specimens analysed showed the low percentages of 0.38 and 0.35, whereas in July and October, 1906, the intervening period being very fine and dry, specimens analysed in those months showed a percentage of 0.54 and 0.64 respectively.

There appears to be no marked variation in alkaloidal contents due to different stages of growth from June to September, except when the plant begins to fade, when there is rapid loss, hence the leaves may be gathered any time from June until the fading of the leaves and shoots set in.

In sowing Belladonna seed, 2 to 3 lb. should be reckoned to the acre. Autumn sown seeds do not always germinate, it is therefore more satisfactory to sow in boxes in a cool house, or frame, in early March, soaking the soil in the seed-boxes first, with boiling water, or baking it in an oven, to destroy the embryo of a small snail which is apt, as well as slugs and various insects, to attack the seedlings later. Pieces of chalk or lime can be placed among the drainage rubble at the bottom of the boxes. Belladonna seed is very slow in germinating, taking four to six weeks, or even longer, and as a rule not more than 70 per cent can be relied on to germinate. On account of the seeds being so prone to attack by insect pests, if sown in the open, the seed-beds should first be prepared carefully. First of all, rubbish should be burnt on the ground, the soil earthed up and fired all over, all sorts of burnt vegetable rubbish being worked in. Then thoroughly stir up the ground and leave it rough for a few days so that air and sun permeate it well. Then level and rake the bed fine and finally give it a thorough drenching with boiling water. Let it stand till dry and friable, add sharp grit sand on the surface, rake fine again and then sow the seed very thinly.

Considerable moisture is needed during germination. The seedlings should be ready for planting out in May, when there is no longer any fear of frost. They will then be about 1 1/2 inch high. Put them in after rain, or if the weather be dry, the ground should be well watered first, the seedlings puddled in and shaded from the sun with inverted flower-pots for several days. About 5,000 plants will be needed to the acre. If they are to remain where first planted, they may be planted 18 inches apart. A reserve of plants should be grown to fill in gaps.

The seedlings are liable to injury by late frosts and a light top dressing of farmyard manure or leaf-mould serves to preserve young shoots from injury during sudden and dangerous changes of temperature. They do best in shade. In America, difficulties in the cultivation of Belladonna have been overcome by interspersing plants with rows of scarlet runners, which, shading the herb, cause it to grow rapidly. Healthy young plants soon become re-established when transplanted, but require watering in dry weather. Great care must be taken to keep the crop clean from weeds and handpicking is to be recommended.

By September, the single stem will be 1 1/2 to 2 1/2 feet high. A gathering of leaves may then be made, if the plants are strong; 'leaves' include the broken-off tops of the plants, but the coarser stems are left on the plant and all discoloured portions rejected, and the plants should not be entirely denuded of leaves.

Before the approach of winter, plants must be thinned to 2 1/2 to 3 feet apart, or overcrowding will result in the second year, in which the plant will bear one or two strong stems.

The writer finds that the green tips and cuttings from side branches root well and easily in early summer, and that buds with a piece of the root attached can be taken off the bigger roots in April, this being a very successful way of rapid propagation to get big, strong plants.

In the second year, in June, the crop is cut a few inches above the ground, while flowering, and delivered to the wholesale buyer the same day it is cut.

The average crop of fresh herb in the second and third years is 5 to 6 tons per acre, and 5 tons of fresh leaves and tops yield 1 ton of dried herb. A second crop is obtained in September in good seasons.

The yield per acre in the first year of growth should average about 6 cwt. of dry leaves.

The greatest loss of plants is in wet winters. Young seedling plants unless protected by dead leaves during the winter often perish. On the lighter soils there is less danger from winter loss, but the plants are more liable to damage from drought in summer.

One of the principal insect pests that attack Belladonna leaves is the so-called 'fleabeetle.' It perforates the leaves to such an extent as to make them unfit for sale in a dried state. It is when the plants are exposed to too much sunlight in open spots that the attacks of the beetle are worst, its natural habitat being well-drained slopes, partly under trees. If therefore the ground around the plants is covered with a thick mulch of leaves, they are not so likely to be attacked. The caterpillars from which the beetles come feed on the ground, and as they dislike moisture, the damp leaves keep them away. If napthalene is scattered on the soil, the vapour will probably help to keep the beetles off. The only way to catch them is to spread greased sheets of paper below the plants, and whenever the plants are disturbed a number of beetles will jump off like fleas and be caught on the papers. This at best only lessens the total quantity, however, and the other methods of precaution are the best.

The plant is dug or ploughed up during the autumn in the fourth year and the root collected, washed and dried, 3 to 4 tons of fresh root yielding a little over 1 ton of dry root. In time of great scarcity, it would probably pay to dig the root in the third year.

Old roots must be replaced by a planting of young ones or offsets, and if wireworm is observed, soot should be dug in with replacements.

Although Belladonna is not a plant that can be successfully grown in every small garden, yet in a chalky garden a few plants might be grown in a shady corner for the sake of the seed, for which there is a demand for propagation. Those, also, who know the haunts of the plant in its wild state might profitably collect the ripe berries, which should then be put into thin cotton bags and the juice squeezed out in running water. When the water is no longer stained, wring the bag well and turn out the seeds on to blotting paper and dry in the sun, or in a warm room near a stove. Sieve them finally, when dry, to remove all portions of the berry skin, etc.

Belladonna has been successfully cultivated in the neighbourhood of Leningrad since 1914, and already good crops have been obtained, the richness of the stems in alkaloids being noteworthy. It is stated that in consequence of the success that has attended the cultivation of Belladonna in Russia, it will no longer be needful to employ German drugs in the preparation of certain alkaloids. Much is also being collected wild in the Caucasus and in the Crimea.

It is hoped that if sufficient stocks can be raised in Britain, not only will it be unnecessary to import Belladonna, but that it may be possible to export it to those of our Dominions where the climate and local conditions prevent its successful culture, though at present it is still included among the medicinal plants of which the exportation is forbidden.

The following note on the growth and cultivation of Belladonna is from the Chemist and Druggist, of February 26, 1921:

'Belladonna is a perennial, but for horticultural purposes it is treated as a biennial, or triennial plant. The root in 3 years has attained very large dimensions around Edinburgh; in fact, often so large as to make the lifting a very heavy, and therefore costly, matter, and in consequence 2 years' growth is quite sufficient. One-year-old roots are just as active as the three-year-old stocks, and to the grower it is merely a matter of expediency which crop he chooses to dig up. The aerial growth is very heavy, twoyear-old plants making 5 to 6 feet in the season if not cut for first crop, and if cut in July they make a second growth of 2 to 3 feet by September. To obtain a supply of seeds certain plantations must be left uncut, so as to get a crop of seeds for the next season. Moisture is, from a practical point of view, a very important matter. A sample, apparently dry to the touch, but not crisp, may have 15 per cent to 20 per cent of moisture present. Therefore if a pharmacist was to use a sample of such Belladonna leaves, although assayed to contain 0.03 per cent of alkaloids, he would produce a weaker tincture than if he had used leaves with, say, only 5 per cent of water present. The alkaloidal factor of this drug is the index to its value. Both the British and the United States Pharmacopoeias adopt the same standard of alkaloidal value for the leaves, but the British Pharmacopceia does not require a standard for the root, which is one of those subtle conundrums which this quaint book frequently presents! Plants grown in a hard climate, such as Scotland, give a good alkaloidal figure, which compares favourably with any others. For roots, the British Pharmacopoeia as just stated, requires no standard, but United States Pharmacopceia standard is 0.45 per cent, and Scottish roots yielded 0.78 per cent and 0.72 per cent. There is not a great deal of alkaloidal value in the stalks. About 0.08 in the autumn.'

---Constituents---The medicinal properties of Belladonna depend on the presence of Hyoscyamine and Atropine. The root is the basis of the principal preparations of Belladonna.

The total alkaloid present in the root varies between 0.4 and 0.6 per cent, but as much as 1 per cent has been found, consisting of Hyoscyamine and its isomer Atropine, 0.1 to 0.6 per cent; Belladonnine and occasionally, Atropamine. Starch and Atrosin, a red colouring principle, are also present in the root. Scopolamine (hyoscine) is also found in traces, as is a fluorescent principle similar to that found in horse-chestnut bark and widely distributed through the natural order Solanaceae. The greater portion of the alkaloidal matter consists of Hyoscyamine, and it is possible that any Atropine found is produced during extraction.

The amount of alkaloids present in the leaves varies somewhat in wild or cultivated plants, and according to the methods of drying and storing adopted, as well as on the conditions of growth, soil, weather, etc.

The proportion of the total alkaloid present in the dried leaves varies from 0.3 to 0.7per cent. The greater proportion consists of Hyoscyamine, the Atropine being produced during extraction, as in the root. Belladonnine and Apoatropine may also be formed during extraction from the drug. The leaves contain also a trace of Scopolamine, Atrosin and starch.

The British Pharmacopoeia directs that the leaves should not contain less than 0.3 per cent of alkaloids and the root not less than 0.45 per cent.

A standardized liquid extract is prepared, from which the official plaster, alcoholic extract, liniment, suppository, tincture and ointment are made. The green extract is prepared from the fresh leaves.

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---Medicinal Action and Uses---Narcotic, diuretic, sedative, antispasmodic, mydriatic. Belladonna is a most valuable plant in the treatment of eye diseases, Atropine, obtained during extraction, being its most important constituent on account of its power of dilating the pupil. Atropine will have this effect in whatever way used, whether internally, or injected under the skin, but when dropped into the eye, a much smaller quantity suffices, the tiny discs oculists using for this purpose, before testing their patient's sight for glasses, being made of gelatine with 1/50000 grain of Atropine in each, the entire disk only weighing 1/50 grain. Scarcely any operation on the eye can safely be performed without the aid of this valuable drug. It is a strong poison, the amount given internally being very minute, 1/200 to 1/100 grain. As an antidote to Opium, Atropine may be injected subcutaneously, and it has also been used in poisoning by Calabar bean and in Chloroform poisoning. It has no action on the voluntary muscles, but the nerve endings in involuntary muscles are paralysed by large doses, the paralysis finally affecting the central nervous system, causing excitement and delirium.

The various preparations of Belladonna have many uses. Locally applied, it lessens irritability and pain, and is used as a lotion, plaster or liniment in cases of neuralgia, gout, rheumatism and sciatica. As a drug, it specially affects the brain and the bladder. It is used to check excessive secretions and to allay inflammation and to check the sweating of phthisis and other exhausting diseases.

Small doses allay cardiac palpitation, and the plaster is applied to the cardiac region for the same purpose, removing pain and distress.

It is a powerful antispasmodic in intestinal colic and spasmodic asthma. Occasionally the leaves are employed as an ingredient of cigarettes for relieving the latter. It is well borne by children, and is given in large doses in whooping cough and false croup.

For its action on the circulation, it is given in the collapse of pneumonia, typhoid fever and other acute diseases. It increases the rate of the heart by some 20 to 40 beats per minute, without diminishing its force.

It is of value in acute sore throat, and relieves local inflammation and congestion.

Hahnemann proved that tincture of Belladonna given in very small doses will protect from the infection of scarlet fever, and at one time Belladonnna leaves were held to be curative of cancer, when applied externally as a poultice, either fresh or dried and powdered.

Belladonna plasters are often applied, after a fall, to the injured or sprained part. A mixture of Belladonna plaster, Salicylic acid and Lead plaster is recommended as an application for corns and bunions.

---Preparations and Dosages---Powdered leaves, 1 to 2 grains. Powdered root, 1 to 5 grains. Fluid extract leaves, 1 to 3 drops. Fluid extract root, B.P., 1/4 to 1 drop. Tincture, B.P., 5 to 15 drops. Alkaloid Atropine, Alcoholic extract, B.P., 1/4 to 1 grain. Green extract, B.P., 1/4 to 1 grain. Juice, B.P., 5 to 15 drops. Liniment, B.P. Plaster, B.P. and U.S.P. Ointment, B.P.

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